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High-speed rail and the city: urban dynamics and tourism () demonstrate that rail service affects 49% of the respondents, after the heritage and architectural At the same date Paris urban area had million of inhabitants. Belgeo [En ligne], 3 | , mis en ligne le 30 septembre , consulté le 01 août
The city is a major railway, highway and air-transport hub served by two international airports: Paris—Charles de Gaulle the second busiest airport in Europe and Paris—Orly. Gare du Nord is the 24th busiest railway station in the world, but the first located outside Japan, with million passengers in Paris received 38 million visitors in , measured by hotel stays, with the largest numbers of foreign visitors coming from the United States, the United Kingdom, Germany and China.
The city hosted the Olympic Games in , and will host the Summer Olympics. The name ‘Paris’ is derived from its early inhabitants, the Gallic Parisii tribe. By , the Grand boulevards were lit. The Parisii , a sub-tribe of the Celtic Senones , inhabited the Paris area from around the middle of the 3rd century BC. It became a prosperous city with a forum, baths, temples, theatres, and an amphitheatre.
Clovis the Frank , the first king of the Merovingian dynasty , made the city his capital from By the end of the 12th century, Paris had become the political, economic, religious, and cultural capital of France. After the marshland between the river Seine and its slower ‘dead arm’ to its north was filled in around the 10th century,  Paris’ cultural centre began to move to the Right Bank.
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We previously reported the development of a new acquired neurogenic HO NHO mouse model, combining spinal cord transection SCI and chemical muscle injury. Pathological mechanisms responsible for ectopic osteogenesis after central neurological damage are still to be elucidated. In this study, we first hypothesized that peripheral nervous system PNS might convey pathological signals from injured spinal cord to muscles in NHO mouse model.
Twenty one C57Bl6 mice were included in this protocol. Bilateral cardiotoxin CTX injection in hamstring muscles was associated with a two-stage surgical procedure, combining thoracic SCI with unilateral peripheral denervation. Volumes of HO Bone Volume, BV were measured 28 days after surgery using micro-computed tomography imaging techniques and histological analyses were made to confirm intramuscular osteogenesis.
Volume comparisons were conducted between right and left hind limb of each animal, using a Wilcoxon signed rank test. Nineteen mice survive the complete SCI and peripheral denervation procedure. Micro-CT measurements showed significantly increased BV in denervated paws 1. Peripheral denervation can be reliably added to spinal cord transection in NHO mouse model.
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